RxAdjacent Labs
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Methodology & evidence

We show our work.

Our programs are built from published guidelines and peer-reviewed research, and we measure every cohort against pre-declared outcomes. Here is what we rely on — and what we don’t claim.

Why this matters: prevalence

47.7%[CDC]

of U.S. adults have hypertension

~1 in 5[CDC]

adults with hypertension are at goal (<130/80)

31%[WHO]

of adults worldwide don’t meet activity guidelines

What the research says about activity and blood pressure

Figures below are from published studies of populations. They describe research findings, not results any individual should expect from our product.

Aerobic activity

~4–7 / 3–4 mmHg[2025]

Average BP difference in study populations cited in the 2025 AHA/ACC guideline (not a prediction for you), which recommends ≥150 min/week of moderate aerobic activity.

Isometric training

8.24 / 4.00 mmHg[Edwards]

Pooled resting BP difference across 270 RCTs (15,827 participants). Wall squat showed the largest systolic difference. Typical protocol: 4 × 2-min holds, 3×/week.

Daily steps

6–8k / day[Paluch]

Where mortality risk associations plateaued for adults 60+ (8–10k for younger adults). Biggest differences at the low end.

Activity trackers

+~1,800 steps[Ferguson]

Average daily increase associated with wearable-based interventions.

Self-efficacy

7 of 9 reviews[Choi][Frontiers]

Most consistent personal correlate of physical activity. Home-exercise adherence OR 1.58.

Habit formation

66 days median[Lally]

Time to automaticity; a missed day did not derail habit formation.

How we design

  1. 01

    Screen first

    ACSM-style pre-participation questions route people to “start light” or “check with your clinician first”.

  2. 02

    Build confidence before intensity

    Mastery experiences in weeks 1–2, mapped to the COM-B model (capability, opportunity, motivation).

  3. 03

    Dose ladder

    Level 1 sitting breaks + short walks → Level 2 anchor routine (isometrics) → Level 3 ~150 min/week. Progress only after completed, comfortable sessions.

  4. 04

    Measure simply

    Steps, 30-second chair stand, home readings with validated-cuff guidance, and confidence.

  5. 05

    Expect attrition, design re-entry

    Digital health has a structural “law of attrition”; we plan restart paths instead of punishing streaks.

Our dose ladder is an internal synthesis of the evidence, not a validated clinical protocol.[Michie][Eysenbach]

Outcomes we measure

Pre-declared for every pilot cohort. We will publish results, including null results.

Week-1 completionTarget > 70% of enrolled users
Week-4 active retentionSurvival curve by cohort
Confidence ratingChange from baseline, 1–10
Ladder progression% reaching level 2 (anchor routine)
Home BP trendChange in 7-day systolic average, weeks 8–12 (descriptive)
Chair standChange in 30-second count
SafetyAll adverse events and flagged readings, reported
Care-team sharing% of users sharing a clinician summary

Pilot results: First cohort launching soon.

What we don’t claim

  • — Our tools do not diagnose, treat, cure, or prevent any disease.
  • — We never recommend starting, stopping, or changing a medication.
  • — Research findings above are not a promise of individual results.
  • — Clinician summaries display trends; interpretation is the clinician’s.

Positioned under FDA’s general wellness policy.[FDA]

Sources

  1. [1]CDC NCHS Data Brief 511 (Hypertension, 2021–2023)
  2. [2]WHO — Physical activity fact sheet
  3. [3]Physical Activity Guidelines for Americans, 2nd ed.
  4. [4]2025 AHA/ACC High Blood Pressure Guideline (JACC)
  5. [5]Edwards et al., BJSM 2023 — network meta-analysis, 270 RCTs
  6. [6]Naci et al., BJSM 2019 — 391 RCTs
  7. [7]Paluch et al., Lancet Public Health 2022 — daily steps
  8. [8]Ferguson et al., Lancet Digital Health 2022 — activity trackers
  9. [9]Choi et al. — systematic review of reviews (self-efficacy)
  10. [10]Frontiers 2023 meta-analysis — home exercise adherence
  11. [11]Lally et al., EJSP 2010 — habit formation
  12. [12]Michie et al., Implementation Science 2011 — COM-B
  13. [13]Riebe et al., MSSE 2015 — ACSM pre-participation screening
  14. [14]CDC STEADI — 30-Second Chair Stand
  15. [15]validatebp.org — validated BP devices
  16. [16]AHA scientific statement — orthostatic hypotension
  17. [17]Pavey et al., JECH 2012 — exercise referral schemes
  18. [18]Eysenbach, JMIR 2005 — the law of attrition
  19. [19]FDA — General Wellness: Policy for Low Risk Devices
  20. [20]FDA — Clinical Decision Support Software guidance
  21. [21]FTC Health Breach Notification Rule (2024)

RxAdjacent Labs tools are general wellness products designed to support physical activity and self-tracking. They are not medical devices, do not diagnose, treat, or cure any condition, and never recommend changes to medication. Talk with your clinician before starting a new activity program and before making any change to your medications.